PATTI LuPONE GUEST STARS -- Frasier (Kelsey Grammer) discovers that the Crane men are not invited to a family wedding because of a grudge Frasier's intense Greek aunt (guest star Patti LuPone, 'Sunset Boulevard') has held against him ever since he gave her son, Nikos (guest star Joseph Will), some advice she didn't like. Feeling responsible for the reason that Martin (John Mahoney) hasn't been able to see his brother for five years, Frasier becomes determined to reunite the family.
This episode introduces us to the Hellenic branch of the Crane clan, Martin's brother Walt and his wife Zora. There is also, crucially, their son Nikos, a young man who, his mother believed, belonged in medicine and a steady marriage. Frasier, however, spoke to him to some length, and the upshot was an uncharacteristic defiance of the maternal will, and a rift between the two sides of the family.