Dr. Frasier Crane, a successful Boston therapist, moves to Seattle following his divorce to get a new start on life; he has a radio talk show, where he relays his wit and wisdom to aide callers, while dealing with a changed homelife living with his salt-of-the-earth father Martin Crane (John Mahoney and the senior Crane's physical therapist Daphne Moon (Jane Leeves). Frasier also reconnects with his sometimes uptight brother Niles Crane (David Hyde Pierce and finds new friends among his colleagues, especially his brash show producer Roz Doyle (Peri Gilpin).
Dr. Frasier Winslow Crane (b. 1952) is a fictional character on American television sitcoms Frasier and Cheers. He was played by Kelsey Grammer for twenty years, tying the record for the longest-running live-action character on prime-time American television, which was set by James Arness, who played Marshal Matt Dillon on the show Gunsmoke. Grammer received Emmy Award nominations for portraying Crane on three different NBC shows, including a 1992 guest appearance on Wings