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Father Mike Mancuso is the host of "Religion on the Line" on KACL 780 talk radio. He appears in only three episodes of the show, but is frequently mentioned during the first three seasons. He first appears when a rumor is spread the someone may be fired from the station. He is initially worried that is himself, but his job is safe for the time. In the second season, he asks Frasier to speak at a hospital fundraiser. In the season premiere of the third season "She's the Boss", Mike is fired by Kate Costas, due to low ratings. He is never seen again after that episode. He received no salary at KACL, taking a "vow of poverty". He is played by George DelHoyo.

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